Top Anti-inflammatory Supplements For Horses

Top Natural Anti-inflammatory Supplements For Horses

Inflammation is at the root of many equine health conditions—from arthritis and soft tissue injuries to metabolic syndrome and laminitis. While NSAIDs like Bute or Equioxx are effective, long-term use can come with side effects like gastric ulcers or kidney strain.

That’s where natural anti-inflammatory supplements come in. They may not replace prescription medications, but they can support horses with chronic inflammation, especially when used under veterinary supervision. Below, we explore research-backed options including turmeric, omega-3 fatty acids, Boswellia, and Devil’s Claw.

Disclaimer
This article is for informational purposes only. Always consult your veterinarian before starting any supplement, especially if your horse is on medication or has a chronic condition.

1. Turmeric

Turmeric, a bright yellow spice, is making its way into many horse feeding routines. The active ingredient, curcumin, has proven anti-inflammatory effects and is used in horses with arthritis, metabolic syndrome, laminitis, ulcers, skin irritations, among others .

Research says that the top benefits from feeding turmeric to your horses are:

  • Beneficial anti-inflammatory properties
  • Metabolic health (supports insulin sensitivity)
  • Plays a role in protecting cartilage integrity.
  • Helps lessen ulceration severity
  • Improves recovery and enhaces training by reducing inflammation

Curcumin is tricky for the body to absorb. Mixing turmeric with fresh ground black pepper (about six turns on a hind grind dispense) and/or 15 ml oil source (like flaxseed oil) improves its uptake. I always start with a small amount, usually just a teaspoon, but a dose up to 2.4 g per day of turmeric is suggested as safe.

Tips for Using Turmeric

  • Start slow, adding about a teaspoon to the feed and slowly increasing if your horse tolerates it up to 2.4g per day.
  • Add 15 ml linseed oil and 1/2 teaspoon black pepper for better absorption.
  • Watch for digestive sensitivity and stop if you see loose manure or signs of discomfort. Although it was initially thought to cause gastric irriation, this theory has been disproven.

If you don’t feel like buying the turmeric, linseed oil and black pepper and preparing it for your horse, then here are some products that contain turmeric for you to enjoy:

Smart & Simple™ Turmeric Pellets (SmartPak Equine) – ★4.6 (+60 reviews on SmartPak)
SmartEquine Smart & Simple Turmeric Pellets
4.6
$141.00 $98.70

An easy way to add natural anti-inflammatory support to your horse’s diet to maintain healthy joints and help manage the discomfort from normal daily exercise and activity. Provides 10,000 mg of turmeric in a mess-free pellet.

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07/26/2025 10:22 am GMT

Dose: Administer 30g daily (1 scoop = 30g)

💰 $39.95 ($0.89 / day) – 3-lb bag (45 day supply)

💰 $70.47 ($0.78 / day) – 6-lb bag (90 day supply)

💰 $141.00 ($0.78 / day) – 12-lb bag (180 day supply)

Pros:
✔ Easy to feed
✔ Clean ingredient list
✔ Supports joint and immune health
✔ Great product, great price

Cons:
No piperine for enhanced absorption
Best fed with a fat source (you can add pepper and linseed oil yourself, or if you’re already feeding a source of fat it’s ok.)

Inactive Ingredients: Alfalfa Meal, Corn Distiller’s Dried Grains with Solubles, Lignin Sulfonate, Sodium Propionate (preservative), Soybean Oil.

Active Ingredients per 30 g:

Ingredient NameAmount Per Serving
Turmeric (Curcuma longa)10,000 mg
Turmericle® Powder by Stance Equine – ★4.3 (+25 reviews on SmartPak and Amazon)
Turmeric Powder for Horses with Powdered Coconut Oil
4.3
$108.50

A potent blend of turmeric, powdered coconut oil, black pepper (piperine), and resveratrol designed to enhance bioavailability and support joint, digestive, and immune health.

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07/26/2025 10:31 am GMT

Dose: 1 scoop = 28 grams

2 scoops per day for a 500kg horse

💰 $97.84 ($2.45 / day) – 5-lb bag (40 day supply)

💰 $210.48 ($1.75 / day) – 15-lb bag (120 day supply)

Pros:
✔ Includes black pepper & coconut oil for proper absorption
✔ Also contains resveratrol for added antioxidant benefits
✔ Great for horses needing support in normal inflammation response

Cons:
✘ Propietary blend
✘ Smell may reduce palatability for picky eaters

Ingredients per scoop:

A propietary blend of:

Turmeric (Curcuma longa & Curcuma xanthorrhiza)

Lauric acid (coconut oil)

Resveratrol (Japanese Knotweed)

Black Pepper (Piper nigrum)

28 g

2. Omega-3 Fatty Acids

Omega 3 fatty acids, found in oils like fish oil and flaxseed oil, offer natural support against inflammation. These good fats help balance the body’s inflammatory response and are used by many owners to help with:

linseed supports a horses coat
  • conditions like arthritis, skin allergies, or even muscle soreness.
  • hearth health and brain function
  • cool calories for exercising horses and hard keepers

I’ve seen clear results when supplementing older horses with stiff joints; movement gets easier, and discomfort after work is less obvious. I normally supplement fish oil to every horse I compete, since it has been proven to lower the Omega 6 fatty acids in horses, which may contribute to health problems like inflammation if the ratio is incorrect.

Fish oil offers EPA and DHA, while flaxseed oil provides ALA. Both types help, but fish oil works more directly because horses convert ALA less efficiently, additionally flaxseed oil can degrade much quicker, needing special care for storing the product.

What to look out for?
It is important for you to check that the omega 6 and omega 3 balance is correct, many “fish oil products” actually contain a significant proportion of soybean oil, which is higher in omega-6 fatty acids; excessive omega-6 intake may promote inflammation

Let me show you some products:

W-3 Oil by Mad Barn – ★4.6 (+900 reviews on MadBarn)
W-3 Oil - Fat Supplement for Horses with Omega-3 | Mad Barn
4.6
$66.99

A plant-based omega-3 oil blend with microalgae-sourced DHA and natural vitamin E. Supports inflammation, immune function, and skin health, also aiding in weight maintenance—without the fishy smell.

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Ingredients: Soybean oil, flax oil, heterotrophic algae, d-alpha-tocopherol (natural vitamin E) and flavour.

Dose:
Maintenance – 100 mL per day per 500 kg
Weight Management – 200 mL per day per 500 kg


💰 $66.99 ($1.34 / day) – 5 L Jug (50 servings)

💰 $228.99 ($1.14 / day) – 20 L Jug (200 servings)

Pros:
✔ Less fishy smell
✔ Includes vitamin E for antioxidant protection
✔ Great for metabolic, joint, and respiratory support

Cons:
✘ Contains soy—check for sensitivities

Active Ingredients:
Per 100 mL serving
IngredientsPer 100 mL
Proprietary Blend of Soybean, flax and DHA Oil99mL
DHA (minimum)1500mg
Vitamin E (d-alpha-tocopherol)1000mg
Wellpride – ★5 (3 reviews on Wellpride) but Highly Reviewed by The Horse
Wellpride Omega-3 For Horses
5.0
$53.95

Highly reviewed by The Horse.

This is a top quality product that is designed to prevent the product from going rancid and smelly like many others, in order to keep all the health benefits from fish oil.

This is a new find! And I am buying one to try it out and then make a separate product review that I will be linking here when I do it.

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Ingredients: Fish Oil, Vitamin E Supplement, Flavor

Dose: 1 to 2 ounces per day for a 500kg horse

Wellpride recommends you finish the 30-ounce bottle within six weeks.


💰 $53.95 ($1.79 / day) – 30 oz Jug (30 day supply)

Pros:
✔ Pump mechanism to prevent oxygen exposure
✔ Top quality, human-grade fish oil
✔ Removed toxinis and heavy metals
Provide Certificate of Analysis

Cons:
✘ Some picky eaters won’t to eat it (although they will refund your first bottle if your horse doesn’t like it).

ANALYTICAL PARAMETERSRESULTSSPECIFICATION
Free Fatty Acids (%)0.09max 0.25
Eicosapentaenoic Acid (EPA)19.9min 18.0
Docosahexaenoic Acid (DHA)12.8min 12.0
Total Omega-3 Fatty Acids (%)40.7min 30.0
Peroxide Value (meq. O2/kg)1.4max 3.5
Anisidine Value8.8max 10.0
TOTOX Value11.6max 15.0
Dioxins (pg (WHO TEQ)/g)conformsmax 1.0
PCB Congeners (28;52;101;118;138;153;180)(mg/kg)conformsmax 0.09
Arsenic (mg/kg)conformsmax 0.1
Mercury (mg/kg)conformsmax 0.005
Lead (mg/kg)conformsmax 0.1
EO-3™ Omega-3 Supplement by KER – ★3.9 (+50 reviews on Amazon)
Kentucky Equine Research EO-3
3.9
$122.50

A highly concentrated marine-derived omega-3 oil rich in EPA and DHA, designed to support joint, metabolic, immune, and reproductive health in horses.

The reason why the reviews are not as high as the others, is that people complain about their horses not eating it. So if this is your preferred product, please buy the smallest version or ask somebody that gives KER to their horses to let you try it with your horse, just in case.

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07/26/2025 10:31 am GMT

Ingredients: Fish Oil, Mixed Tocopherols, Artificial Flavor

Dose: Add 1 oz (30 mL) per day to the feed of 500-kg horses


💰 $53.95 ($1.68 / day) – 32 oz Jug (32 day supply)

💰 $128.95 ($1.00 / day) – 1 Gal Jug (128 day supply)

💰 $589.95 ($0.92 / day) – 3 Gal Jug (640 day supply)

Pros:
✔ Research-backed by KER
✔ Excellent omega-3 source for reducing inflammation
✔ EO-3’s minty apple is four times as palatable as the original
✔ Omega-3 Omega-6 ratio 8:1

Cons:
✘ Some picky eaters refuse to eat it

Guaranteed AnalysisConcentrationper 30 mL
Fat98%27.0 g
Omega-3 fatty acids32%5,800 mg
Eicosapentaenoic Acid (EPA)3,200 mg
Docosahexaenoic Acid (DHA)2,300 mg
Omega-6 fatty acid4%700 mg
Omega-3:Omega-6 ratio8:1
Omega Horseshine® – ★4.8 (+850 reviews on SmartPak)
Omega Horseshine®
4.8
$31.53


Omega Horseshine was Horse Journal's product of the year. And you can see from reading it's reviews how popular and liked it is!

It is a fortified, stabilized ground flaxseed supplement rich in ALA omega-3 fatty acids, benefiting:

  • Healthy skin and shiny coat
  • Mares and foals in gestation, lactation and growth
  • Support performance
  • Strong hooves


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Ingredients: Ground Flaxseed, Biotin, Yeast Culture, Zinc Methionine Complex, Ground Oats, Calcium Carbonate, Lysine, Copper Lysine Complex, Sodium Selenite, Folic Acid, Niacinamide, Manganese Sulfate, Calcium Pantothenate, Pyrdidoxine Hydrochloride (Vitamin B-6), Vitamin B-12 Supplement, and Riboflavin.

Dose:

Maintenance: 1/2 – 1 cup, top dressed over feed for 500kg horse
Active: 1-3 cups per day depending on weight


💰 $31.53 ($0.88 / day) – 4.5-lb Bag (36 day supply)

💰 $63.11 ($0.39 / day) – 20-lb Bag (160 day supply)

💰 $136.79 ($0.38 / day) – 45-lb Bag (360 day supply)

Pros:
✔ High-quality, stabilized flax—no rancidity issues
✔ Excellent for coat shine and hoof strength (10mg of biotin per serving)
✔ Rich in fiber for gut support

✔ Low NSC (4.4%) for IR/Cushing’s horses

Cons:
✘ Lower DHA/EPA compared to marine-based oils

Guaranteed Analysis:

Ingredient NameAmount Per Pound
Crude Protein, Min.20.00%
Crude Fat, Min.38.00%
Crude Fiber, Max.15.00%
ADF, Max.19.00%
NDF, Max.24.00%
Dietary Starch. Max.2.30%
Sugar, Max.3.60%
Calcium, Min.0.50%
Calcium, Max.0.55%
Phosphorous, Min.0.59%
Magnesium, Min.0.35%
Potassium, Min.0.74%
Potassium, Max.0.76%
Copper, Min.139.00 ppm
Selenium, Min.2.70 ppm
Zinc, Min.343.00 ppm
Manganese, Min.126.00 ppm
Moisture, Max.6.80%
Omega-3 Fatty Acids, Min.18.50%
Omega-6 Fatty Acids, Min.6.00%
Omega-9 Fatty Acids, Min.6.00%
Biotin64.00 mg
SmartOmega 3 & E™ Ultra – ★4.4 (+125 reviews on SmartPak)
SmartOmega 3 & E Ultra
4.4
$54.68

This producted is designed to promove wellness and vitality to your horse by providing two fundamental ingredients for this: Omega 3s from flaxseed, chia seed and fish oil, along with 1,500 IU of natural vitamin E, to support healthy muscles and a strong immune system.

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Ingredients: Flaxseed Meal, Fish Oil Powder, D-Alpha Tocopherol, Fish Oil, Chia Seed, Fenugreek, Mixed Tocopherols (preservative).

Dose: Feed 30.5g daily (1 scoop = 30.5g)


💰 $54.68 ($0.98 / day) – 3.8-lb Bag (56 day supply)

💰 $104.16 ($0.93 / day) – 7.5-lb Bag (112 day supply)

Pros:
✔ Contains Vitamin E
✔ Promotes overall wellnes and vitality
✔ Convenient form to feed

Cons:
✘ Contains lower amounts of DHA than the products mentioned above

Guaranteed Analysis per 30.5 g:

Ingredient NameAmount Per Serving
Crude Protein (Min)15%
Crude Fat (Min)32%
Crude Fiber (Max)23%
Alpha-Linolenic Acid (an Omega 3 Fatty Acid) (Min)21% (6,500 mg)
Eicosapentaenoic Acid (EPA) (Min)1.5% (465 mg)
Docosahexaenoic Acid (DHA) (Min)1% (310 mg)
Oleic Acid (an Omega 9 Fatty Acid) (Min)5% (1,600 mg)
Linoleic Acid (an Omega 6 Fatty Acid) (Min)4% (1,300 mg)
Vitamin E (Min)1,500 IU

Best Practices for Supplementing Omega 3s

  • Introduce slowly to avoid digestive upset.
  • Use high quality, cold pressed oil and store it in a cool, dark place to prevent spoilage.
  • Always pair fish oil with sufficient vitamin E to prevent oxidative stress.
  • Check with your vet if your horse is on other medications or a special diet.

3. Boswellia Serrata

Boswellia, an herbal extract from the resin of the Boswellia Serrata Tree, is used globally to manage joint and muscle discomfort. Boswellic acids, its active compounds, are believed to limit the enzymes behind swelling and pain. Many equine joint supplements include Boswellia because it’s gentle on the stomach and unlikely to cause side effects seen with some medications.

I give Platinum Performace CJ, that has boswellia content included as part of the formula. It is a very recommended and highly reviewed product that my vet always asks me to give my showjumpers, specially the ones that are going to be competing frequently and high.

Let me show you products that use Boswellia Serrata:

Platinum Performance® CJ ★5 (+125 reviews on Platinum Performance)
Platinum Performance® CJ
5.0
$179.00

This is a top-tier supplement for healthy, performance, or hard-keeping horses needing support for:

  • Hooves and coat
  • Joint function
  • Muscle tone and topline
  • Immune and antioxidant support

Some owners swear by this product, claiming improved joint health and increased mobility, while others find it expensive and suggest exploring alternative, potentially more cost-effective options with similar ingredients.

Buy in Platinum Performance


Dose: 2 scoops once a day or give 1 scoop twice a day (1 scoop (78g)) for a 500kg horse

Recommended for use within 5 months of manufacture date. The 135lb size is recommended for supplementing more than four horses daily.

💰 $179.00 ($6.17 / day) – 10-lb Bag (58 servings)

💰 $316.00 ($6.25 / day) – 17.5-lb Bag (101 servings)

💰 $449.00 ($6.19 / day) – 25-lb Bag (145 servings)

💰 $899.00 ($6.2 / day) – 50-lb Bag (290 servings)

💰 $2190.00 ($5.57 / day) – 135-lb Bag (785 servings)

Pros:
✔ Contains Boswellia serrata for joint support and healthy levels of inflammation
✔ MSM for joint suppport and healthy skin and coat
✔ HA and ASU to reduce bone friction and support cartilage

Cons:
✘ Higher cost than basic joint supplements
✘ Even though it’s a multipurpose supplement, it is not a ration balancer. So if the horse is not fed a balanced diet, you might not see results


Joint Support Blend:**

Per 2 scoops
Glucosamine Sulfate 2KCl8,820 mg
Methylsulfonylmethane (MSM)8,200 mg
Avocado/Soy Unsaponifiables2,000 mg
Boswellia Serrata Extract1,400 mg
Cetyl Myristoleate275 mg
Hyaluronic Acid90 mg
Active Ingredients per 2 scoop serving (156g)
Flaxseed64 g
Joint Support Blend **23.4 g
Stabilized Rice Bran21 g
Omega-3 Fatty Acids (Flax Oil)12 g
Bentonite11 g
Sunflower Kernel6.8 g
Omega-6 Fatty Acids (Flax Oil)6 g
L-Lysine (Lysine Hydrochloride)729 mg
Vitamin C (Absorbic Acid)715 mg
Zinc (Zinc Amino Acid Complex)151 mg
Manganese (Manganese Citrate)130 mg
Calcium (Calcium Carbonate)124 mg
Vitamin B5 (Calcium D-Pantothenic Acid)46 mg
Vitamin B3 (Niacin)21 mg
Vitamin B6 (Pyridoxine Hydrochloride)20 mg
Copper (Copper Amino Acid Complex)16 mg
Vitamin B2 (Riboflavin)10 mg
Folic Acid8 mg
Vitamin B1 (Thiamine Mononitrate)6 mg
DL-Methionine4 mg
Magnesium (Magnesium Gluconate)4 mg
Biotin3 mg
Cobalt (Cobalt Chelate)1.04 mg
Iodine (Potasium Iodide)0.9 mg
Selenium (Selenium Yeast)0.8 mg
Choline (Choline Bitartrate)0.24 mg
Vitamin B120.06 mg
Vitamin A5,000 IU
Vitamin D31,500 IU
Vitamin E (D-Alpha-Tocopheryl Acetate)1,000 IU
Cosequin® ASU by Nutramax – ★4.7 (300+ reviews on Amazon)
Nutramax Cosequin ASU
4.7
$139.99

Cosequin® is the #1 veterinarian recommended joint health supplement brand by a survey conducted among equine veterinarians who recommended oral joint health supplements. 

Cosequin ASU is veterinarian formulated with avocado/soybean unsaponifiables (ASU), glucosamine, chondroitin sulfate, methylsulfonylmethane (MSM), and boswellia serrata extract to provide joint health support for equine athletes

Similar to Platinum Performance but this is a more specialized product targetic only joint support and inflammation.

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07/26/2025 10:32 am GMT

Inactive Ingredients: Dextrose, lecithin, mixed tocopherols, natural and artificial flavor, silicon dioxide, and soy protein isolate.

Dose: Maintenance 1 scoop (16.2 g) daily

💰 $65.99 ($3.77 / ounce) – 500g (1.1lb)

💰 $139.99 ($3.03 / ounce) – 1300g (2.86lbs)


Pros:
✔ Veterinarian recommended
✔ High quality ingredients
✔ Joint support and inflammation

Cons:
✘ Contains dextrose and soy – watch for sensitivities

IngredientAmount per 2 Scoops – 32.4g
Glucosamine Hydrochloride14,400 mg
Methylsulfonylmethane (MSM)10,000 mg
Chondroitin Sulfate2,400 mg
Avocado/Soybean Unsaponifiables (ASU)2,100 mg
Boswellia serrata Extract560 mg
Manganese100 mg

Acti-flex Powder by Cox Vet Labs – ★4.8 (+100 reviews on Amazon)
Cox Acti-Flex Joint Supplement
4.8
$60.31

Acti-flex Powder works against inflammation and pain, but it is also designed to give long term protection to joints and cartilage, by helping prevent cumulative cartilage damage during performance years.

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07/26/2025 10:40 am GMT

Ingredients: Glucosamine Sulfate, Chondroitin Sulfate A, Chondroitin Sulfate C, Ester C (Ascorbic Acid), Methylsulfonylmethane (MSM), Perna Canaliculus, Manganese Sulfate, Hydrolyzed Gelatine, Hyaluronic Acid, Boswellia Serrata, Tricalcium Phosphate, Eicosapentaenoic Acid, Docosahexaenoic Acid Omega 3 Fatty Acid, DL-Methionine, Dehydrated Alfalfa Meal, Calcium Silicate, Natural and Artificial Flavoring Added.

Dose: 1 – 2oz per day depending on results

💰 $60.30 ($0.75 / serving) – 5-lb Bag (80 servings)


Pros:
✔ Support for inflammation and mobility
✔ Includes Boswellia for added anti-inflammatory benefit
✔ Includes Hyaluronic Acid and Green-Lipped Mussel

Cons:
✘ Uses hydrolyzed gelatine instead of specifi amino acids like lysine and methionine

Guaranteed Analysis (Per Oz.)
Glucosamine Sulfate8,000 mg.
Chondroitin4,000 mg.
MSM3,000 mg.
Ester C (Ascorbic Acid)1,000 mg.
Perna Canaliculus1,000 mg.
Manganese500 mg.
Calcium Silicate250 mg.
Hyaluronic Acid (HA)125 mg.
Boswellia Serrata100 mg.

4. Devil’s Claw

Devil’s Claw is a South African plant with a reputation for helping horses with chronic stiffness, joint pain, or even mild laminitis. The active compounds, called harpagosides, are linked to a reduction in discomfort from everyday wear and tear or old injuries.

Many horses respond quickly to Devil’s Claw, especially those with mild arthritis. It shouldn’t be given to pregnant mares, horses with gastric ulcers, or those on blood thinners without a vet’s approval.

🚨 Important Note:
Devil’s Claw is prohibited in FEI/USEF competitions due to its COX-inhibitory (NSAID-like) action. Always observe appropriate withdrawal times if your horse competes.

To Remember

  • Follow the feeding instructions and weigh out each portion for accuracy.
  • Stop use at least 72 hours before competitions if you show under organizations that restrict its use.
  • Always talk to your veterinarian before starting Devil’s Claw in horses with ulcers or metabolic issues.

It is harder to get in the US or Canada than in Europe. Let me show you:

SmartComfort Pellets by SmartPak – ★4.5 (+300 reviews on SmartPak)
SmartComfort Pellets by SmartPak
4.5
$61.00

A well-rounded joint and comfort formula featuring Boswellia serrata, turmeric, devil’s claw, and yucca—targeting everyday inflammation, stiffness, and discomfort.

It also provides strong antioxidants like as vitamin C and turmeric to fight oxidative stress and support a healthy response to inflammation.

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Inactive Ingredients Alfalfa Meal, Corn Distiller Grains with Solubles, Calcium Propionate (a preservative), Fenugreek Seed Powder, Lignin Sulfonate, Vegetable Oil (cold pressed).

Dose: Administer 56g daily, 1 scoop = 56g


💰 $61.00 ($1.36 / day) – 5.6-lb Bag (45 day supply)

💰 $109.42 ($1.22 / day) – 11.2-lb Bag (90 day supply)

Pros:
✔ Combines multiple natural anti-inflammatories
✔ Includes MSM and omega-3s for joint support
✔ Pellet form is easy to feed

Cons:
✘ Contains devil’s claw—check with your vet if competing

Active Ingredients per 56g:

Ingredient NameAmount Per Serving
Methylsulfonylmethane (MSM)5,000 mg
Yucca Schidigera Extract3,000 mg
Devil’s Claw Extract*2,500 mg
Turmeric Root Powder2,000 mg
DL-Phenylalanine1,500 mg
Boswellia Extract500 mg
Vitamin C (Calcium Ascorbate)500 mg
Cetylated Fatty Acids200 mg
Bromelain50 mg
White Willow Herb Powder50 mg
Marshmallow Root40 mg
Devil’s Claw Plus Pellets by SmartPak – ★4.5 (+300 reviews on Amazon)
Devil's Claw Plus Pellets by SmartPak
4.5
$44.16

Devils Claw Plus’s potent blend of herbal extracts and antioxidants may aid in supporting connective tissues from free radicals and promoting comfortable movement.

This targeted herbal formula combining devil’s claw, Boswellia serrata, and yucca may give support joint comfort and manage occasional stiffness and discomfort in active or older horses.

Buy in Amazon Buy in SmartPak
07/26/2025 10:40 am GMT

Inactive Ingredients: Alfalfa Meal, Citric Acid (preservative), Coconut Oil, Corn Distillers Dried Grains with Solubles, Grape Pomace, Lignin Sulfonate, Magnesium Silicate, Natural and Artificial Flavors, Soybean Oil, Mixed Tocopherols (preservative).

Dose: 1 scoop = 30 g

One scoop daily for maintenance on a 500kg horse.

💰 $47.32 ($1.58 / day) – 2-lb Bag (30 day supply)

💰 $93.63 ($1.25 / day) – 5-lb Bag (75 day supply)

💰 $263.11 ($0.88 / day) – 20-lb Bag (300 day supply)

Pros:
✔ Natural support for inflammation and mobility
✔ Includes Boswellia for added anti-inflammatory benefit
✔ Pellets are easy to feed

Cons:
✘ Not for pregnant mares or horses on NSAIDs
✘ Devil’s claw may be banned in competitive events
✘ Contains Corn Distillers and Soy for Sensitive Horses

Active Ingredients per 30 g (1 scoop):

Ingredient NameAmount Per Serving
Devils Claw Extract (Harpagophytum procumbens) *2,600 mg
Cat’s Claw (Uncaria tomentosa)1,000 mg
Vitamin C (Asorbic Acid)1,000 mg
Boswellia Extract (Boswellia serrata)500 mg
Grape Seed Extract (Vitis vinifera)500 mg
Vitamin B5 (Calcium Pantothenate)500 mg
Yucca Extract (Yucca schidigera)320 mg
Turmeric (Curcuma longa)250 mg
White Willow (Salix alba)150 mg
Hilton Herbs Multi-Flex ★4.5 (+30 reviews on Amazon and Hilton Herbs)
Hilton Herbs Multi-Flex
5.0
$55.99


An herbal blend designed to support joint mobility and comfort. Features Boswellia serrata, meadowsweet, hawthorn, devil’s claw, and milk thistle for natural anti-inflammatory and circulatory benefits.

  • Joints & Healthy Circulation.
  • The body's normal healthy response to inflammation
  • Connective Tissues, Tendons & Ligaments.
  • Soft Tissue Health & Function.
  • Optimum Mobility & General Comfort.
  • Horses & Ponies prone to Founder.


Buy on Amazon Buy on Hilton Herbs
07/24/2025 07:57 pm GMT

Active Ingredients per 50 ml scoop (provided). A Proprietary Formula containing:, Devils Claw Root, Hawthorn Flowering Tops, Meadowsweet Herb, Milk Thistle Seed, Nettle Leaf, Cleaver Herb, Celery Seed, Dandelion Root.

Pros:
✔ Herbal formula with Boswellia and devil’s claw
✔ Supports joints, circulation, and liver health
✔ Available in dry herb or liquid tincture

Cons:
✘ Devil’s claw may be prohibited in competition
✘ Strong herbal scent may deter picky eaters

5. Yucca: Plant Extract for Natural Comfort

Yucca schidigera is a desert plant that contains saponins and polyphenols, both tied to anti-inflammatory effects. Yucca extracts often appear in blends for horses that need extra joint or muscle support. Owners use yucca to help with:

  • Arthritis or degenerative joint disease
  • Soft tissue inflammation
  • Laminitis (chronic cases)
  • Poor manure consistency or mild gut dysbiosis
  • Start with low end of the range, especially if combined with other herbs.
  • Best administered with feed for better absorption and reduced GI irritation.
  • Avoid long-term use at high doses due to potential saponin-related GI irritation.

Yucca Saponin by SmartPak Equine – ★4.6 (+75 reviews on SmartPak and Amazon)
Yucca Saponin by SmartPak
4.6
$47.32

Yucca Saponin contains 10% Yucca Schidigera extract. May support a healthy inflammatory response during normal daily exercise and activity. 

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07/24/2025 07:57 pm GMT

Ingredients: Corn Distiller Grains with Solubles, Magnesium Silicate, Aspergillus Niger Extract, Natural Flavors, Bacillus Subtils Extract, Aspergillus Oryzae Extract.

Dose: 1 scoop= approximately 1 oz of Yucca Saponin

Feed 1/2 oz – 1 oz of Yucca Saponin daily.

Maintenance dose is 1/2 oz


💰 $47.32 ($0.30 / day) – 5-lb Bag (160 day supply)

Pros:
✔ Digestive Enzymes
✔ Probiotic bacteria to support gut health

Cons:
✘ DDGS (Corn Distiller Grans with Solubles)

Guaranteed Analysis per maintenance 1 scoop (1/2 oz) in SmartPaks

Ingredient NameAmount Per Serving
Yucca Schidigera Extract1,400 mg
Absorbine® Bute-Less® Pellets – ★4.6 (+2100 reviews on Amazon)
Bute-Less Comfort & Recovery Pellets
4.6
$21.99 $20.99

Wow! This is such a popular product! So many people are using it and talking about Bute-Less.

This is an incredible alternative for horses that is formulated for long-term use and uses natural ingredients like evil's claw, vitamin B-12, and yucca to help ease aches and discomfort associated with normal daily exercise and activity and training

Helps support a healthy inflammatory response.

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07/24/2025 07:57 pm GMT

Inactive Ingredients: Apple Flavor, Calcium Propionate (preservative), Dehydrated Alfalfa Meal, Dried Molasses, Soybean Oil, Wheat Middlings

Dose: Administer 1 scoop daily for an adult horse weighing 1,100 lb (500 kg)


💰 $21.04 ($0.66 / day) – 2-lb Bag (32 day supply)

💰 $45.25 ($0.57 / day) – 5-lb Bag (80 day supply)

💰 $83.15 ($0.52 / day) – 10-lb Bucket (160 day supply)

Pros:
✔ Natural alternative that is gentle on the stomach
✔ Reviews report often reducing or eliminating the need for daily NSAIDs

Cons:
✘ Contains Molasses and Soy careful with Sensitive Horses
✘ Prohibited in competition, please consult your vet*

Active Ingredients Per 1 oz:

Ingredient NameAmount Per Serving
Yucca Schidigera Extract690 mg
Devil’s Claw Extract*350 mg
Vitamin B-1220 mcg
SmartComfort Pellets by SmartPak (+300 reviews on SmartPak)
SmartComfort Pellets by SmartPak
4.5
$61.00

A well-rounded joint and comfort formula featuring Boswellia serrata, turmeric, devil’s claw, and yucca—targeting everyday inflammation, stiffness, and discomfort.

It also provides strong antioxidants like as vitamin C and turmeric to fight oxidative stress and support a healthy response to inflammation.

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Inactive Ingredients Alfalfa Meal, Corn Distiller Grains with Solubles, Calcium Propionate (a preservative), Fenugreek Seed Powder, Lignin Sulfonate, Vegetable Oil (cold pressed).

Dose:


💰 $61.00 ($1.36 / day) – 5.6-lb Bag (45 day supply)

💰 $109.42 ($1.22 / day) – 11.2-lb Bag (90 day supply)

Pros:
✔ Combines multiple natural anti-inflammatories
✔ Includes MSM and omega-3s for joint support
✔ Pellet form is easy to feed

Cons:
✘ Contains devil’s claw—check with your vet if competing

Active Ingredients per 56g:

Ingredient NameAmount Per Serving
Methylsulfonylmethane (MSM)5,000 mg
Yucca Schidigera Extract3,000 mg
Devil’s Claw Extract*2,500 mg
Turmeric Root Powder2,000 mg
DL-Phenylalanine1,500 mg
Boswellia Extract500 mg
Vitamin C (Calcium Ascorbate)500 mg
Cetylated Fatty Acids200 mg
Bromelain50 mg
White Willow Herb Powder50 mg
Marshmallow Root40 mg

Contraindications:

  • Not recommended in pregnant mares (due to possible uterine stimulation).
  • Horses with pre-existing GI ulcers should be monitored closely.

Avoid for competition unless certified FEI safe.


6. MSM (Methylsulfonylmethan): Sulfur Based Support for Tissues

MSM is a naturally occurring sulfur found in plants and animals, and is known for helping muscles, tendons, and joints recover from exercise. This supplement is often used for horses with:

  • Osteoarthritis and degenerative joint disease
  • Muscle soreness and exercise recovery
  • Allergic skin conditions
  • Laminitis and hoof health (via collagen and keratin synthesis)

Horses deficient in sulfur may show signs such as joint pain, slow post-exercise recovery, or poor hoof quality—conditions often linked to inflammation or tissue degeneration. It’s considered one of the safest equine supplements, with no reported toxicity. Because of its short half-life, any excess MSM is quickly excreted in the urine and feces.

MSM supplementation can be especially helpful for horses with arthritis, aging joints, or compromised hoof health. Research in humans suggests it may also slow cartilage breakdown, potentially delaying the progression of arthritis. For performance horses, MSM is commonly used to reduce inflammation and oxidative stress, helping muscles recover more efficiently after intense work.

I don’t supplement MSM separately for my horses because it’s already one of the key ingredients in Platinum CJ. That said, I’ve used pure MSM in the past—like Uckele’s MSM Powder—and saw great results. It was easy to mix into their feed, but I found it too inconvenient to manage separate supplements for my competition horses. Most owners report noticeably smoother movement and improved flexibility after a few weeks of consistent use.

MadBarn MSM – ★4.9 (+350 reviews on MadBarn)
MSM Supplement for Horses | Mad Barn
4.9
$21.99

This product is designed to support healthy joints, tendons and ligaments in your horse, as they perform and age. It is not a magical cure or supposed to heal anything, it will help your healthy horse remain healthy while remaining active.


MadBarn's recommendation:

For additional joint support, feed MSM with our w-3 Oil, which contains high levels of the omega-3 fatty acid DHA, as well as natural Vitamin E. Combining MSM with w-3 Oil support normal homeostatic regulation of inflammatory processes.

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Dose: 1 scoop = 9 cc = 7 grams

Top dress once daily on feed or ration. 10g for a 500kg horse

💰 $21.99 ($0.22 / day) – 1kg (2.2lb Bag) 100 servings
💰 $43.98 ($0.22 / day) – 2kg (4.4lb Bag) 200 servings
💰 $99.99 ($0.20 / day) – 5kg (11lb Bag) 500 servings

Pros:
✔ Supports your horse’s comfort
✔ Promotes competition readiness
✔ Backed by research

Cons:
✘ May need to add another product if you want more support
✘ Subtle effects

IngredientPer 10 g – 1 1/2 Scoop
Methylsulfonylmethane (MSM)10,000 mg
SmartFlex® Rehab Pellets – ★4.6 (+325 reviews on SmartPak)
SmartFlex® Rehab Pellets
4.6
$88.37

This product is designed for a horse's rehabilitation by supporting the healing process of the horse, by combating the oxidative stress associated with recovery, support bones, tendons, and ligaments; maintain a healthy inflammatory response and encourage normal healing.

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Inactive Ingredients: Alfalfa Meal, Corn Distiller’s Dried Grains with Solubles, Lignin Sulfonate, Sodium Propionate (preservative), Soybean Meal (cold pressed).

Dose: Administer 80g daily, 1 scoop = 40g (2 scoops daily for a 500kg horse)

💰 $88.37 ($3.16 / day) – 5-lb Bag (28 day supply)

💰 $156.79 ($2.80 / day) – 10-lb Bucket (56 day supply)

Pros:
✔ Natural alternative that is gentle on the stomach
✔ Reviews report often reducing or eliminating the need for daily NSAIDs

Cons:
✘ Contains DDGS and Soy (careful with Sensitive Horses)
✘ Prohibited in competition, please consult your vet*

Active Ingredients per 80 g:

Ingredient NameAmount Per Serving
Methylsulfonylmethane (MSM)12,000 mg
Glucosamine HCl (Shellfish)5,000 mg
L-Lysine3,000 mg
Yucca Extract (Yucca schidigera)3,000 mg
Citrus Bioflavanoids2,000 mg
Hydrolyzed Collagen2,000 mg
L-Threonine2,000 mg
Devil’s Claw Extract* (Harpagophytum procumbens)1,500 mg
Vitamin C (Ascorbic Acid)1,000 mg
L-Glutamine1,000 mg
DL-Methionine1,000 mg
Boswellia Extract (Boswellia serrata)750 mg
Silica (Orthosilicic Acid & Magnesium silicate)700 mg
Chondroitin Sulfate (Bovine)400 mg
Omega 3 Fatty Acids300 mg
Quercetin295 mg
Bromelain150 mg
Sodium Hyaluronate (HA)100 mg
White Willow Extract100 mg
Marshmallow Root Powder40 mg
SmartFlex® Senior Herb-Free Pellets – ★4.6 (+350 reviews on SmartPak)
SmartFlex® Senior Herb-Free Pellets
4.6
$62.44

SmartFlex® Senior Pellets are a highly rated joint supplement formulated specifically for aging horses, but this herb-free version is perfect for older horses that are still competing.

This supplement also targets stiffness, inflammation, and joint discomfort. But it adds a bit extra for the sporty senior horse. Palatable and easy to feed.

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Inactive Ingredients: Alfalfa Meal, Corn Distiller’s Dried Grains with Solubles, Lignin Sulfonate, Sodium Propionate (preservative), Soybean Oil (cold pressed).

Dose: Administer 60g daily (1 scoop = 60g) (500 kg horse)

💰 $62.44 ($2.23 / day) – 1.7kg (3.4lb Bag) SmartPak
💰 $105.21 ($1.88 / day) – 3.3kg (7.4lb Bag)
💰 $199.95 ($1.79 / day) – 6.7kg (14.8lb Bag)

Pros:
✔ Product targeted for seniors competing
✔ Well reviewed by owners

Cons:
✘ Contains DDGS and Soy (careful with Sensitive Horses)

Active Ingredients per 60 g:

Ingredient NameAmount Per Serving
Methylsulfonylmethane (MSM)12,000 mg
Glucosamine HCl (Shellfish)8,000 mg
Vitamin C (Ascorbic Acid)750 mg
Chondroitin Sulfate (Bovine)700 mg
DL-Phenylalanine500 mg
Super Oxide Dismutase100 mg
Sodium Hyaluronate (HA)75 mg


7. Arnica: Tropical Support for Acute Swelling

Arnica plant, where topical arnica is made of

Arnica montana is well known for use in topical gels or sprays for acute injuries. Think bumps, bruises, or sore muscles. While it’s not something I feed, I keep arnica gel in my tack room for after strenuous rides or minor knocks, and I’ve noticed it helps reduce swelling and speed up surface recovery time. Always check the skin for any broken areas, since arnica shouldn’t go on wounds.

Applying arnica is easy; simply follow the instructions on the label, massage gently into the sore area, and track your horse’s response. I’ve also talked with professionals who say that while arnica works externally, it helps your horse feel more comfortable after an intense day.


How to Choose the Right Supplement for Your Horse

Choosing the right supplement really comes down to your horse’s age, workload, and specific needs. But before I add anything to their diet, I always start by making sure the base diet is balanced—that’s one of the most common mistakes I see. Many people turn to supplements hoping for a quick fix, when in reality, the issue often stems from a deficiency in the core diet. In those cases, you’re just spending more money to compensate for something that should have been corrected at the foundation.

Once I’m confident the diet is balanced, I get clear on my goal. Am I trying to improve coat quality? Support joints and muscles ahead of more intense training? That focus helps guide my decision. I also always consult my vet before starting anything new and introduce one new ingredient at a time, over a week or two. That way, I can monitor for any side effects or sensitivities early on and make informed adjustments if needed.

  • Check for third party testing to confirm quality and avoid hidden contaminants.
  • Stick to one change at a time, so you can attribute any improvements or side effects to the right source.
  • Consult with a vet, especially when dealing with chronic health problems or performance horses subject to competition rules.
  • Look at your feeding program as a whole, and consider what might be missing in your horse’s nutrition that is causing or contributing to inflammation.

It’s a good idea to keep a simple journal of what you add or remove from your horse’s program, and note any observable changes or patterns. This extra step really helps you track down what works best for your horse.


*Here’s a little transparency: Our website contains affiliate links. This means if you click and make a purchase, we may receive a small commission. Don’t worry, there’s no extra cost to you. It’s a simple way you can support our mission to bring you quality content ** 


References
  • Farinacci, M., Gaspardo, B., Colitti, M., & Stefanon, B. (2009). Dietary administration of curcumin modifies transcriptional profile of genes involved in inflammatory cascade in horse leukocytes. Italian Journal of Animal Science, 8(sup2), 84–86. https://doi.org/10.4081/ijas.2009.s2.84
  • Fletcher, S. P. S., & Gough, S. L. (2019). Pre-treatment with turmeric (Curcuma xanthorrhiza) reduces the severity of squamous gastric ulceration in feed-restricted horses. Journal of Animal Science Research. https://sciforschenonline.org/journals/animal-science-research/JASR125.php
  • Starzonek, J., Roscher, K., Blüher, M., Blaue, D., Schedlbauer, C., Hirz, M., Raila, J., & Vervuert, I. (2019). Effects of a blend of green tea and curcuma extract supplementation on lipopolysaccharide-induced inflammation in horses and ponies. PeerJ, 7, e8053. https://doi.org/10.7717/peerj.8053
  • Tinworth, K. D., Harris, P. A., Sillence, M. N., & Noble, G. K. (2010). Potential treatments for insulin resistance in the horse: A comparative multi-species review. The Veterinary Journal, 186(3), 282–291. https://doi.org/10.1016/j.tvjl.2009.08.032
  • Weisberg, S. P., Leibel, R., & Tortoriello, D. V. (2008). Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology, 149(7), 3549–3558. https://doi.org/10.1210/en.2008-0262
  • Smith, A. G., Miles, V. N., Holmes, D. T., Chen, X., & Lei, W. (2021). Clinical Trials, Potential Mechanisms, and Adverse Effects of Arnica as an Adjunct Medication for Pain Management. Medicines (Basel, Switzerland)8(10), 58. https://doi.org/10.3390/medicines8100058
  • “Arnica – an Overview | ScienceDirect Topics.” Sciencedirect.com, 2016, www.sciencedirect.com/topics/agricultural-and-biological-sciences/arnica, https://doi.org/10.1016/B978-0-323-02998-8.50025-1. Accessed 18 June 2025.
  • Axmann, Sonja, et al. “Pharmacokinetics of Harpagoside in Horses after Intragastric Administration of a Devil’s Claw (Harpagophytum Procumbens) Extract.” Journal of Veterinary Pharmacology and Therapeutics, vol. 42, no. 1, 22 Sept. 2018, pp. 37–44, https://doi.org/10.1111/jvp.12716. Accessed 22 May 2019.
  • Beghelli, Daniela, et al. “Dietary Supplementation with Boswellia Serrata, Verbascum Thapsus, and Curcuma Longa in Show Jumping Horses: Effects on Serum Proteome, Antioxidant Status, and Anti-Inflammatory Gene Expression.” Life, vol. 13, no. 3, 10 Mar. 2023, pp. 750–750, https://doi.org/10.3390/life13030750. Accessed 21 Nov. 2023.
  • Cheeke, PR, et al. “Anti-Inflammatory and Anti-Arthritic Effects of Yucca Schidigera: A Review.” Journal of Inflammation, vol. 3, no. 1, 29 Mar. 2006, https://doi.org/10.1186/1476-9255-3-6.
  • Dr. Priska Darani. “17 Science-Backed Benefits of Omega-3 Fatty Acids in Horses | Mad Barn.” Mad Barn USA, 20 Sept. 2020, madbarn.com/omega-3-benefits-for-horses/?srsltid=AfmBOornwsdNaBJP0ubcEColuq06zNoVHdHJSX-8aK6DMCT0HWmRXi4c. Accessed 18 June 2025.
  • Marañón, Gonzalo, et al. “The Effect of Methyl Sulphonyl Methane Supplementation on Biomarkers of Oxidative Stress in Sport Horses Following Jumping Exercise.” Acta Veterinaria Scandinavica, vol. 50, no. 1, 2008, p. 45, https://doi.org/10.1186/1751-0147-50-45. Accessed 20 Sept. 2020.
  • Miller, Rachel, et al. “93 Comparison of Physiological Responses to Exercise in Horses on a Conditioning Regimen versus Inactive Horses Receiving a Yucca and Fenugreek Dietary Supplement.” Journal of Animal Science, vol. 97, no. Supplement_1, July 2019, pp. 30–30, https://doi.org/10.1093/jas/skz053.066. Accessed 23 Mar. 2021.
  • O’Connor, C. I., et al. “Dietary Fish Oil Supplementation Affects Serum Fatty Acid Concentrations in Horses1.” Journal of Animal Science, vol. 85, no. 9, 1 Sept. 2007, pp. 2183–2189, https://doi.org/10.2527/jas.2006-528.
  • —. “The Effect of Dietary Fish Oil Supplementation on Exercising Horses.” Journal of Animal Science, vol. 82, no. 10, 1 Oct. 2004, pp. 2978–2984, https://doi.org/10.2527/2004.82102978x. Accessed 9 Nov. 2021.
  • Oke, Stacey. “Pain Management in the Performance Horse.” The Horse, 11 Mar. 2023, thehorse.com/1121501/pain-management-in-the-performance-horse/. Accessed 18 June 2025.
  • Pearson, Garett, et al. “Dose-Dependent Increase in Whole Blood Omega-3 Fatty Acid Concentration in Horses Receiving a Marine-Based Fatty-Acid Supplement.” Journal of Equine Veterinary Science, vol. 108, Jan. 2022, p. 103781, https://doi.org/10.1016/j.jevs.2021.103781. Accessed 10 Dec. 2021.
  • Roy, Nand Kishor, et al. “An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.” International Journal of Molecular Sciences, vol. 20, no. 17, 22 Aug. 2019, p. 4101, https://doi.org/10.3390/ijms20174101.
  • SmartPak Equine. “Importance of Omega 3 & 6 Fatty Acids for Horses – SmartPak.” SmartPak Equine, 2024, www.smartpakequine.com/learn-health/omega-3-and-6-fatty-acids-for-horses?srsltid=AfmBOopGhms_YnqbvV4QX5dZbvbBqs7Uu_AfMEuF87cIJaqY0wv3ZipR. Accessed 18 June 2025.
  • Warren, Helen, and L Codner. “Effect of Yucca (Yucca Schidigera) on Ammonia Levels from Equine Excreta in the Stable.” EAAP Scientific Series, vol. 132, Jan. 2012, pp. 343–346, https://doi.org/10.3920/978-90-8686-755-4_45.
  • Young, Amy. “Supplementing for Joint Health: What the Science Says.” Horse Report / School of Veterinary Medicine, 9 Aug. 2021, cehhorsereport.vetmed.ucdavis.edu/news/supplementing-joint-health-what-science-says.

 

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